v. 42 n. 2 (2022)
Artigos

Contextualismo sexual

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  • Sarah S. Richardson
Sarah S. Richardson
Department of the History of Science, Harvard University, Cambridge, USA
DOI: https://doi.org/10.36446/af.2022.687

Publicado 2022-11-11

Creative Commons License

Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.

Resumo

En este artículo se desarrolla el marco conceptual del “contextualismo sexual” para el estudio de las variables relacionadas con el sexo en la investigación biomédica. El contextualismo sexual ofrece una alternativa a los enfoques sexuales binarios y esencialistas del estudio del sexo como variable biológica. Específicamente, el contextualismo sexual reconoce el pluralismo y la especificidad contextual que tienen las operacionalizaciones de “sexo” a través de la investigación experimental de laboratorio. A la luz de recientes normativas para la consideración del sexo como variable biológica, el contextualismo sexual ofrece una guía constructiva a los/as investigadores/as biomédicos/as para abordar la variación biológica relacionada con el sexo. En tanto alternativa y crítica al esencialismo binario del sexo biológico, el contextualismo sexual contribuye a los debates actuales en filosofía de la biología, estudios feministas de la ciencia y ontología social en torno a la construcción de categorías de la diferencia sexual/genérica en la investigación científica.

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Referências

  1. Barad, K. (1996). Meeting the universe halfway: Realism and social constructivism without contradiction. Feminism, science, and the philosophy of science (pp. 161-194). Springer.
  2. Bösch, F., Angele, M. K., & Chaudry, I. H. (2018). Gender differences in trauma, shock and sepsis. Military Medical Research, 5(1), 1-10. https://doi.org/10.1186/s40779-018-0182-5
  3. Butler, J. (2019). What threat? The campaign against ‘gender ideology’. Glocalism: Journal of Culture, Politics, and Innovation, 3, 1-12. https://doi.org/10.12893/gjcpi.2019.3.1
  4. Columbia University (2019). Genes that drive male-female brain differences and timing of puberty. Neuroscience News. Recuperado el 19 de enero de 2021.
  5. Clayton, J. A., & Collins, F. S. (2014). Policy: NIH to balance sex in cell and animal studies. Nature, 509(7500), 282-283. https://doi.org/10.1038/509282a
  6. de Vries, G. J., & Forger, N. G. (2015). Sex differences in the brain: A whole body perspective. Biology of sex differences, 6(1), 1-15. https://doi.org/10.1186/s13293-015-0032-z
  7. Eliot, L., & Richardson, S. S. (2016). Sex in context: Limitations of animal studies for addressing human sex/gender neurobehavioral health disparities. Journal of Neuroscience, 36(47), 11823-11830. https://doi.org/10.1523/JNEUROSCI.1391-16.2016
  8. Epstein, S. (2007). Inclusion: The politics of difference in medical research. University of Chicago Press.
  9. Fuller, C. M., & Insel, P. A. (2014). I don’t know the question, but sex is definitely the answer! Focus on “In pursuit of scientific excellence: sex matters” and “Do you know the sex of your cells?”. American Journal of Physiology-Cell Physiology, 306(1), C1-C2. https://doi.org/10.1152/ajpcell.00342.2013
  10. Green, E. L., Benner, K., & Pear, R. (2018, Octubre 22). Trump may limit how government defines one’s sex. The New York Times, A.
  11. Ha, N. Q., Dworkin, S. L., Martínez-Patiño, M. J., Rogol, A. D., Rosario, V., Sánchez, F. J., & Vilain, E. (2014). Hurdling over sex? Sport, science, and equity. Archives of sexual behavior, 43(6), 1035-1042. https://doi.org/10.1007/s10508-014-0332-0
  12. Hansen, J. (2015, Octubre 21). Female sex hormone may save injured soldiers on the battlefield. University of Alabama News Portal. https://www.uab.edu/news/research/item/6625-Female-Sex-Hormone-May-Save-Injured-Soldiers-on-the-Battlefield
  13. Haslanger, S. (2000). Gender and race: (What) are they? (What) do we want them to be? Noûs, 34(1), 31-55. https://doi.org/10.1111/0029-4624.00201
  14. Haslanger, S. (2015). Theorizing with a purpose: The many kinds of sex. En C. Kendig (Ed.), Natural kinds and classification in scientific practice (pp. 149-164). Routledge.
  15. Hawkins, D. (2017, Marzo 31). An Anti-Transgender ‘Free Speech Bus’ Is Rolling Through the East Coast. The Washington Post.
  16. Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics, 19(6), 371-384. https://doi.org/10.1038/s41576-018-0004-3
  17. Katsnelson, A. (2014). Male researchers stress out rodents. Nature. https://doi.org/10.1038/nature.2014.15106
  18. Landecker, H. (2000). Immortality, in vitro: A history of the HeLa cell line. En P. E. Brodwin (Ed.), Biotechnology and culture: Bodies, anxieties, ethics (pp. 53-72). Indiana University Press.
  19. Lucey, B. P., Nelson-Rees, W. A., & Hutchins, G. M. (2009). Henrietta Lacks, HeLa cells, and cell culture contamination. Archives of pathology & laboratory medicine, 133(9), 1463-1467. https://doi.org/10.5858/133.9.1463
  20. Mauvais-Jarvis, F., Arnold, A. P., & Reue, K. (2017). A guide for the design of pre-clinical studies on sex differences in metabolism. Cell metabolism, 25(6), 1216-1230. https://doi.org/10.1016/j.cmet.2017.04.033
  21. McCarthy, M. M., & Arnold, A. P. (2011). Reframing sexual differentiation of the brain. Nature neuroscience, 14(6), 677-683. https://doi.org/10.1038/nn.2834
  22. McKinnon, K. E. (2020). EVATAR: The mother of microhumans. Recuperado el 1º de noviembre de 2000.
  23. Naqvi, S., Godfrey, A. K., Hughes, J. F., Goodheart, M. L., Mitchell, R. N., & Page, D. C. (2019). Conservation, acquisition, and functional impact of sex-biased gene expression in mammals. Science, 365(6450), eaaw7317. https://doi.org/10.1126/science.aaw7317
  24. National Institutes of Health. (2016). Reviewer guidance to evaluate sex as a biological variable (SABV). https://grants.nih.gov/grants/peer/guidelines_general/sabv_decision_tree_for_reviewers.pdf
  25. Office of Research on Women’s Health. (2020). Sex & Gender. National Institutes of Health. https://orwh.od.nih.gov/sex-gender
  26. Pape, M. (2021). Co-production, multiplied: Enactments of sex as a biological variable in US biomedicine. Social Studies of Science, 51(3), 339-363. https://doi.org/10.1177/03063127209859
  27. Pape, M., Latham, J. R., Karkazis, K., & Ritz, S. (2020). Resisting and remaking sex in the petri dish, the clinic, and on the track. Catalyst: feminism, theory, technoscience, 6(2), 1-17.
  28. Pereira, L., Aeschimann, F., Wang, C., Lawson, H., Serrano-Saiz, E., Portman, D. S., & Hobert, O. (2019). Timing mechanism of sexually dimorphic nervous system differentiation. eLife, 8, e42078. https://doi.org/10.7554/eLife.42078
  29. Pollitzer, E. (2013). Cell sex matters. Nature, 500(7460), 23-24. https://doi.org/10.1038/500023a
  30. Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014). Female mice liberated for inclusion in neuroscience and biomedical research. Neuroscience & Biobehavioral Reviews, 40, 1-5. https://doi.org/10.1016/j.neubiorev.2014.01.001
  31. Rabin, R. C. (2014, Mayo 15). Labs are told to start including a neglected variable: Females. The New York Times, 1A.
  32. Richardson, S. S. (2013). Sex itself: The search for male and female in the human genome. University of Chicago Press.
  33. Richardson, S. S., Reiches, M., Shattuck-Heidorn, H., LaBonte, M. L., & Consoli, T. (2015). Focus on preclinical sex differences will not address women’s and men’s health disparities. Proceedings of the National Academy of Sciences, 112(44), 13419-13420. https://doi.org/10.1073/pnas.1516958112
  34. Ritz, S. A. (2016). Complexities of addressing sex in cell culture research. Signs: Journal of Women in Culture and Society, 42(2), 307-327. https://doi.org/10.1086/688181
  35. Shah, K., McCormack, C. E., & Bradbury, N. A. (2014). Do you know the sex of your cells? American Journal of Physiology-Cell Physiology, 306(1), C3-C18. https://doi.org/10.1152/ajpcell.00281.2013
  36. Skloot, R. (2010). The immortal life of Henrietta Lacks. Crown Publishers.
  37. Sorge, R. E., Martin, L. J., Isbester, K. A., Sotocinal, S. G., Rosen, S., Tuttle, A. H. y Mogil, J. S. (2014). Olfactory exposure to males, including men, causes stress and related analgesia in rodents. Nature methods, 11(6), 629-632. https://doi.org/10.1038/nmeth.2935
  38. Sudai, M. (2019). Toward a functional analysis of ‘sex’ in federal antidiscrimination law. Harvard Journal of Law and Gender, 42(2), 421.
  39. Tannenbaum, C., Schwarz, J. M., Clayton, J. A., de Vries, G. J., & Sullivan, C. (2016). Evaluating sex as a biological variable in preclinical research: The devil in the details. Biology of sex differences, 7(1), 1-4. https://doi.org/10.1186/s13293-016-0066-x
  40. Tayag, Y. (2017, Marzo 18). Scientists built a vagina on a tablet. Inverse. https://www.inverse.com/article/29624-vagina-female-reproductive-system-organ-on-chip-evatar
  41. Waltz, M., Saylor, K. W., Fisher, J. A., & Walker, R. L. (2021). Biomedical researchers perceptions of the NIH’s sex as a biological variable policy for animal research: Results from a US national survey. Journal of Women’s Health, 30(10), 1395-1405. https://doi.org/10.1089/jwh.2020.8997
  42. Woitowich, N. C., & Woodruff, T. K. (2019). Implementation of the NIH sex-inclusion policy: Attitudes and opinions of study section members. Journal of Women’s Health, 28(1), 9-16. https://doi.org/10.1089/jwh.2018.7396
  43. Xiao, S., Coppeta, J. R., Rogers, H. B., Isenberg, B. C., Zhu, J., Olalekan, S. A. & Woodruff, T. K. (2017). A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Nature communications, 8(1), 1-13. https://doi.org/10.1038/ncomms14584